| ncRNA name | KCNQ1OT1 |
| ncRNA Category | lncRNA |
| ID | 10984 |
| Ensembl | ENSG00000269821 |
| Synonyms | LIT1; Kncq1; KvDMR1; KCNQ10T1; KCNQ1-AS2; KvLQT1-AS; NCRNA00012 |
| Disease name | cataract |
| Species | Homo sapiens |
| Tissues/Cell_line | lens posterior capsular samples; human lens epithelial cell line SRA01/04 |
| Methods | transfection, RT‑qPCR, immunohistochemical staining, Western blot, EdU incorporation assay, CCK‑8 assay |
| Expression pattern | up-regulated |
| Functional description | The function of KCNQ1OT1 was to act on LEC proliferation and EMT, and this was achieved via the SMAD4 signaling pathway. Suppression of KCNQ1OT1 inhibited the proliferation and EMT of TGF-β2-treated SRA01/04 cells. |
| PubMed ID | 29749509 |
| Year | 2018 |
| Title | Long noncoding RNA KCNQ1OT1 promotes proliferation and epithelial‑mesenchymal transition by regulation of SMAD4 expression in lens epithelial cells. |
| Drug-related ncRNA | NO |
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